Last update
2/28/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 2 Reviews
8.3
Supplement Facts
Serving Size: 2 Tablets
Amount Per Serving
%DV
Calories
10
Total Carbohydrate
2 g
<1%*
Glucosamine Hydrochloride
2,000 mg
†
Hyaluronic Acid
3.3 mg
†
Top Medical Research Studies
8
We engaged in a pilot study comparing the effectiveness of polynucleotide sodium with sodium hyaluronate for knee osteoarthritis pain relief. With 15 patients divided into three groups, all received ultrasound-guided injections over three weeks.
Our findings showed that those treated with polynucleotide sodium experienced a significant reduction in weight-bearing pain compared to the hyaluronic acid group after six weeks. However, the other measures of pain and quality of life did not exhibit notable differences between the groups.
Overall, polynucleotide sodium proved more effective in alleviating weight-bearing pain in this limited study.
Our findings showed that those treated with polynucleotide sodium experienced a significant reduction in weight-bearing pain compared to the hyaluronic acid group after six weeks. However, the other measures of pain and quality of life did not exhibit notable differences between the groups.
Overall, polynucleotide sodium proved more effective in alleviating weight-bearing pain in this limited study.
Read More
Most Useful Reviews
7.5
Immediate relief
For bone health, I regularly purchase Schiff's glucosamine-coated tablets and calcium. When my joints feel stiff and inflexible, taking them provides immediate relief.
Read More
7
Gradual improvement
Works notably well with MSM, which can be taken separately. I felt an effect after a week of taking 1 gram twice daily. The improvement was gradual and noticeable, though not miraculous for severely worn bones.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
- All Researches
8
We engaged in a pilot study comparing the effectiveness of polynucleotide sodium with sodium hyaluronate for knee osteoarthritis pain relief. With 15 patients divided into three groups, all received ultrasound-guided injections over three weeks.
Our findings showed that those treated with polynucleotide sodium experienced a significant reduction in weight-bearing pain compared to the hyaluronic acid group after six weeks. However, the other measures of pain and quality of life did not exhibit notable differences between the groups.
Overall, polynucleotide sodium proved more effective in alleviating weight-bearing pain in this limited study.
Our findings showed that those treated with polynucleotide sodium experienced a significant reduction in weight-bearing pain compared to the hyaluronic acid group after six weeks. However, the other measures of pain and quality of life did not exhibit notable differences between the groups.
Overall, polynucleotide sodium proved more effective in alleviating weight-bearing pain in this limited study.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Immediate relief
For bone health, I regularly purchase Schiff's glucosamine-coated tablets and calcium. When my joints feel stiff and inflexible, taking them provides immediate relief.
Read More
7
Gradual improvement
Works notably well with MSM, which can be taken separately. I felt an effect after a week of taking 1 gram twice daily. The improvement was gradual and noticeable, though not miraculous for severely worn bones.
Read More
Frequently Asked Questions
7
Gradual improvement
Works notably well with MSM, which can be taken separately. I felt an effect after a week of taking 1 gram twice daily. The improvement was gradual and noticeable, though not miraculous for severely worn bones.
8
We engaged in a pilot study comparing the effectiveness of polynucleotide sodium with sodium hyaluronate for knee osteoarthritis pain relief. With 15 patients divided into three groups, all received ultrasound-guided injections over three weeks.
Our findings showed that those treated with polynucleotide sodium experienced a significant reduction in weight-bearing pain compared to the hyaluronic acid group after six weeks. However, the other measures of pain and quality of life did not exhibit notable differences between the groups.
Overall, polynucleotide sodium proved more effective in alleviating weight-bearing pain in this limited study.
Our findings showed that those treated with polynucleotide sodium experienced a significant reduction in weight-bearing pain compared to the hyaluronic acid group after six weeks. However, the other measures of pain and quality of life did not exhibit notable differences between the groups.
Overall, polynucleotide sodium proved more effective in alleviating weight-bearing pain in this limited study.
References
- Kim JY, Kim YN, Lee YJ, Sim SE, Ko YR, et al. Pilot Study to Evaluate the Efficacy of Polynucleotide Sodium Compared to Sodium Hyaluronate and Crosslinked Sodium Hyaluronate in Patients with Knee Osteoarthritis. J Clin Med. 2021;10. 10.3390/jcm10051138
Data last updated:
